Preparation and Characterization of Natural Silk Fibroin Hydrogel for Protein Drug Delivery.

ABSTRACT: In recent years, hydrogels have been widely used as drug carriers, especially in the area of protein delivery. The natural silk fibroin produced from cocoons of the Bombyx mori silkworm possesses excellent biocompatibility, significant bioactivity, and biodegradability. Therefore, silk fibroin-based hydrogels are arousing widespread interest in biomedical research. In this study, a process for extracting natural silk fibroin from raw silk textile yarns was established, and three aqueous solutions of silk fibroin with different molecular weight distributions were successfully prepared by controlling the degumming time. Silk fibroin was dispersed in the aqueous solution as "spherical" aggregate particles, and the smaller particles continuously accumulated into large particles. Finally, a sil

SUBMITTER: Liu J 

PROVIDER: S-EPMC9181960 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature