Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestations.

ABSTRACT: Severe cases of Coronavirus Disease 2019 (COVID-19) can present with multiple neurological symptoms. The available neuropathological studies have described different lesions; the most frequent was the presence of neuroinflammation and vascular-related lesions. The objective of this study was to report the neuropathological studies performed in a medical institution, with abundant long intensive care unit stays, and their associated clinical manifestations. This is a retrospective monocentric case series study based on the neuropathological reports of 13 autopsies with a wide range of illness duration (13-108 days). A neuroinflammatory score was calculated based on the quantification of CD8- and CD68-positive cells in representative areas of the central nervous system. This score was correl

SUBMITTER: Ruz-Caracuel I 

PROVIDER: S-EPMC9182090 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature