Casiopeinas of Third Generations: Synthesis, Characterization, Cytotoxic Activity and Structure-Activity Relationships of Mixed Chelate Compounds with Bioactive Secondary Ligands.

ABSTRACT: Casiopeinas are a family of copper(II) coordination compounds that have shown an important antineoplastic effect and low toxicity in normal cells. These compounds induce death cells by apoptosis through a catalytic redox process with endogenous reducing agents. Further studies included a structural variation, improving the activity and selectivity in cancer cells or other targets. In the present work we report the third generation, which contains a bioactive monocharged secondary ligand, as well as the design, synthesis, characterization and antiproliferative activity, of sixteen new copper(II) coordination compounds with curcumin or dimethoxycurcumin as secondary ligands. All compounds were characterized by elemental analysis, FTIR, UV-Vis, magnetic susceptibility, mass spectra with MALDI

SUBMITTER: Figueroa-DePaz Y 

PROVIDER: S-EPMC9182210 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature