Causality of anthropometric markers associated with polycystic ovarian syndrome: Findings of a Mendelian randomization study.

ABSTRACT:

Introduction

Using body mass index (BMI) as a proxy, previous Mendelian randomization (MR) studies found total causal effects of general obesity on polycystic ovarian syndrome (PCOS). Hitherto, total and direct causal effects of general- and central obesity on PCOS have not been comprehensively analyzed.

Objectives

To investigate the causality of central- and general obesity on PCOS using surrogate anthropometric markers.

Methods

Summary GWAS data of female-only, large-sample cohorts of European ancestry were retrieved for anthropometric markers of central obesity (waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR)) and general obesity (BMI and its constituent variables-weight and height), from the IEU Open GWAS Project. As the outcome, we acqu

SUBMITTER: De Silva K 

PROVIDER: S-EPMC9182303 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature