Humoral response to mRNA vaccines against SARS-CoV-2 in patients with humoral immunodeficiency disease.

ABSTRACT:

Objectives

Although mRNA-based vaccines against SARS-CoV-2 induce a robust immune response and prevent infections and hospitalizations, there are limited data on the antibody response in individuals with humoral immunodeficiency. The aim of this study was to evaluate the humoral immune response after two vaccine doses with BNT162b2 or mRNA-1273 in patients with humoral immunodeficiency disease.

Methods

This cross-sectional study assessed 39 individuals with hypogammaglobulinemia under immunoglobulin replacement therapy. IgG anti-SARS-CoV-2 spike protein antibodies (anti-S) were measured 4 weeks to 4 months after two doses of an mRNA vaccine against SARS-CoV-2. The proportion of patients, who developed a humoral immune response to the spike protein were evaluated and compared

SUBMITTER: Bitzenhofer M 

PROVIDER: S-EPMC9182562 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature