Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation.

ABSTRACT: Cells sense and integrate external information from diverse sources that include mechanical cues. Shaping of tissues during development may thus require coordination between mechanical forces from morphogenesis and cell-cell signalling to confer appropriate changes in gene expression. By live-imaging Notch-induced transcription in real time, we have discovered that morphogenetic movements during Drosophila gastrulation bring about an increase in activity-levels of a Notch-responsive enhancer. Mutations that disrupt the timing of gastrulation resulted in concomitant delays in transcription up-regulation that correlated with the start of mesoderm invagination. As a similar gastrulation-induced effect was detected when transcription was elicited by the intracellular domain NICD, it can

SUBMITTER: Falo-Sanjuan J 

PROVIDER: S-EPMC9183233 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature