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The efficacy and safety of IBI314 on delta and omicron variant of SARS-CoV-2: First-in-human evidence.

ABSTRACT:

SUBMITTER: Sang L

PROVIDER: S-EPMC9183246 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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The efficacy and safety of IBI314 on delta and omicron variant of SARS-CoV-2: First-in-human evidence.

Sang Ling L Cheng Bo B Yu Yuheng Y Xi Yin Y Wang Yun Y Fan Bingdong B Li Jijie J Dai Jingtao J Gan Guifen G Tong Shijun S Sun Bin B Qi Xiaojing X Liang Wenhua W He Jianxing J Zhong Nanshan N

The Journal of infection 20220609 3

PMID: 35691517

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Project description:IntroductionIn November 2021, the SARS-CoV-2 Omicron variant of concern has emerged and is currently dominating the COVID-19 pandemic over the world. Omicron displays a number of mutations, particularly in the spike protein, leading to specific characteristics including a higher potential for transmission. Although Omicron has caused a significant number of deaths worldwide, it generally induces less severe clinical signs compared to earlier variants. As its impact on blood platelets remains unknown, we investigated platelet behavior in severe patients infected with Omicron in comparison to Delta.MethodsClinical and biological characteristics of severe COVID-19 patients infected with the Omicron (n=9) or Delta (n=11) variants were analyzed. Using complementary methods such as flow cytometry, confocal imaging and electron microscopy, we examined platelet activation, responsiveness and phenotype, presence of virus in platelets and induction of selective autophagy. We also explored the direct effect of spike proteins from the Omicron or Delta variants on healthy platelet signaling.ResultsSevere Omicron variant infection resulted in platelet activation and partial desensitization, presence of the virus in platelets and selective autophagy response. The intraplatelet processing of Omicron viral cargo was different from Delta as evidenced by the distribution of spike protein-positive structures near the plasma membrane and the colocalization of spike and Rab7. Moreover, spike proteins from the Omicron or Delta variants alone activated signaling pathways in healthy platelets including phosphorylation of AKT, p38MAPK, LIMK and SPL76 with different kinetics.DiscussionAlthough SARS-CoV-2 Omicron has different biological characteristics compared to prior variants, it leads to platelet activation and desensitization as previously observed with the Delta variant. Omicron is also found in platelets from severe patients where it induces selective autophagy, but the mechanisms of intraplatelet processing of Omicron cargo, as part of the innate response, differs from Delta, suggesting that mutations on spike protein modify virus to platelet interactions.

Dataset Information

The efficacy and safety of IBI314 on delta and omicron variant of SARS-CoV-2: First-in-human evidence.

Publications

The efficacy and safety of IBI314 on delta and omicron variant of SARS-CoV-2: First-in-human evidence.

Similar Datasets

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