Transgenic mice encoding modern imaging probes: Properties and applications.

ABSTRACT: Modern biology is increasingly reliant on optical technologies, including visualization and longitudinal monitoring of cellular processes. The major limitation here is the availability of animal models to track the molecules and cells in their natural environment in vivo. Owing to the integrity of the studied tissue and the high stability of transgene expression throughout life, transgenic mice encoding fluorescent proteins and biosensors represent unique tools for in vivo studies in norm and pathology. We review the strategies for targeting probe expression in specific tissues, cell subtypes, or cellular compartments. We describe the application of transgenic mice expressing fluorescent proteins for tracking protein expression patterns, apoptotic events, tissue differentiation and regener

SUBMITTER: Kasatkina LA 

PROVIDER: S-EPMC9183799 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature