Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study.

ABSTRACT:

Background

Individual cardiometabolic disorders and genetic factors are associated with an increased dementia risk; however, the relationship between dementia and cardiometabolic multimorbidity is unclear. We investigated whether cardiometabolic multimorbidity increases the risk of dementia, regardless of genetic risk, and examined for associated brain structural changes.

Methods

We examined health and genetic data from 203 038 UK Biobank participants of European ancestry, aged 60 years or older without dementia at baseline assessment (2006-10) and followed up until March 31, 2021, in England and Scotland and Feb 28, 2018, in Wales, as well as brain structural data in a nested imaging subsample of 12 236 participants. A cardiometabolic multimorbidity index comprising stroke,

SUBMITTER: Tai XY 

PROVIDER: S-EPMC9184258 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature