Population-based incidence and risk factors for cholestasis in hemolytic disease of the fetus and newborn.

ABSTRACT:

Objective

To estimate the incidence of cholestasis in neonates with hemolytic disease of the fetus and newborn (HDFN) and investigate risk factors and long-term liver disease.

Study design

A population-based cohort study of all infants born with HDFN within the Stockholm region between 2006 and 2015. The study period was the first 90 days of life, and presence of any chronic liver disease was evaluated at two years of age.

Results

Cholestasis occurred in 7% (11/149). Median age at detection was 1.1 days. Intrauterine blood transfusions and maternal alloimmunization with multiple red blood cell antibodies including D-, c- or K-antibodies were independent risk factors for cholestasis. No infant had chronic liver disease at two years of age.

Conclusions

Infants wi

SUBMITTER: Teng J 

PROVIDER: S-EPMC9184269 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature