NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH.

ABSTRACT:

Background and aims

NASH is a common disease associated with increased rates of thromboembolism (TE). Although exercise training can lessen thrombotic risk in patients with vascular disease, whether similar findings are observed in patients with NASH is open for study.

Approach and results

We conducted a 20-week randomized controlled clinical trial involving patients with biopsy-confirmed NASH. Patients were randomly assigned (2:1 ratio) to receive either an exercise training program or standard clinical care. The primary endpoint was change in plasminogen activator inhibitor 1 (PAI-1) level, an established thrombotic biomarker. Twenty-eight patients were randomly assigned (18 exercise training and 10 standard clinical care). PAI-1 level was significantly decreased by exerci

SUBMITTER: Stine JG 

PROVIDER: S-EPMC9184303 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature