Statin discontinuation in persons with and without Alzheimer's disease.

ABSTRACT:

Background

Although statin use is reported to decrease after dementia diagnosis, time to statin discontinuation and factors associated with discontinuation have not been studied in persons with Alzheimer's disease (AD). We compared the risk of discontinuation and factors associated with discontinuation, including secondary and primary prevention indication, in statin users with and without AD.

Methods

The register-based Medication Use and Alzheimer's Disease (MEDALZ) cohort includes community dwellers with a clinically verified AD diagnosed during 2005-2011 in Finland. On the AD diagnosis date (index date), each person with AD was matched with a comparison person without AD. We included 25,137 people with AD and 22,692 without AD who used statin on the index date or initiate

SUBMITTER: Vu M 

PROVIDER: S-EPMC9184400 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature