Mortality-based definition of renal hyperfiltration in middle-aged men: a 35-year cohort from Finland.

ABSTRACT:

Background

While the impact of low glomerular filtration rate (eGFR) on various outcomes has been extensively studied, the other adverse occurrence, renal hyperfiltration (RHF), remains understudied, poorly defined, and, therefore, its impact on mortality unestablished.

Methods

Using a population-based subcohort from the Kuopio Ischaemic Disease Risk Factor Study restricted to non-diabetic Finnish men aged 54 or 55 years, we followed up n = 1179 study participants for up to 35 years. We evaluated the hazard of all-cause mortality associated to RHF at different cutoff points defining eGFR. Based on models' accuracy we suggested an optimal eGFR cutoff point for the definition of RHF. We divided the RHF category to three subgroups and evaluated them in terms of baseline charact

SUBMITTER: Ould Setti M 

PROVIDER: S-EPMC9184436 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature