Dietary restriction ameliorates TBI-induced phenotypes in Drosophila melanogaster.

ABSTRACT: Traumatic brain injury (TBI) affects millions annually and is associated with long-term health decline. TBI also shares molecular and cellular hallmarks with neurodegenerative diseases (NDs), typically increasing in prevalence with age, and is a major risk factor for developing neurodegeneration later in life. While our understanding of genes and pathways that underlie neurotoxicity in specific NDs has advanced, we still lack a complete understanding of early molecular and physiological changes that drive neurodegeneration, particularly as an individual ages following a TBI. Recently Drosophila has been introduced as a model organism for studying closed-head TBI. In this paper, we deliver a TBI to flies early in adult life, and then measure molecular and physiological phenotypes at short-,

SUBMITTER: Delventhal R 

PROVIDER: S-EPMC9184478 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature