Donor-dependent fecal microbiota transplantation efficacy against necrotizing enterocolitis in preterm pigs.

ABSTRACT: The development of necrotizing enterocolitis (NEC), a life-threatening inflammatory bowel disease affecting preterm infants, is connected with gut microbiota dysbiosis. Using preterm piglets as a model for preterm infants we recently showed that fecal microbiota transplantation (FMT) from healthy suckling piglet donors to newborn preterm piglets decreased the NEC risk. However, in a follow-up study using donor stool from piglets recruited from another farm, this finding could not be replicated. This allowed us to study donor-recipient microbiota dynamics in a controlled model system with a clear difference in NEC phenotype. Preterm piglets (n = 38) were randomly allocated to receive control saline (CON), or rectal FMT using either the ineffective (FMT1) or the effective donor stool (FMT2).

SUBMITTER: Hui Y 

PROVIDER: S-EPMC9184500 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature