Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder.

ABSTRACT: Gene expression covaries with brain activity as measured by resting state functional magnetic resonance imaging (MRI). However, it is unclear how genomic differences driven by disease state can affect this relationship. Here, we integrate from the ABIDE I and II imaging cohorts with datasets of gene expression in brains of neurotypical individuals and individuals with autism spectrum disorder (ASD) with regionally matched brain activity measurements from fMRI datasets. We identify genes linked with brain activity whose association is disrupted in ASD. We identified a subset of genes that showed a differential developmental trajectory in individuals with ASD compared with controls. These genes are enriched in voltage-gated ion channels and inhibitory neurons, pointing to excitation-inhibiti

SUBMITTER: Berto S 

PROVIDER: S-EPMC9184501 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature