Waning effectiveness of the third dose of the BNT162b2 mRNA COVID-19 vaccine.

ABSTRACT: The duration of protection of the third (booster) dose of the BioNTech/Pfizer BNT162b2 mRNA Coronavirus Disease 2019 vaccine has been the subject of recent investigations, as global discussions around the necessity and effectiveness of a fourth dose are already underway. By conducting a retrospective study implementing a test-negative case-control design, analyzing 546,924 PCR tests performed throughout January 2022 by 389,265 persons who received at least two doses, we find that the effectiveness in each month-since-vaccination decreases significantly. Compared to those vaccinated five months prior to the outcome period, on August 2021, relative protection against infection waned from 53.4% a month after vaccination to 16.5% three months after vaccination. These results suggest that there

SUBMITTER: Patalon T 

PROVIDER: S-EPMC9184525 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature