Biophysical mechanism underlying compensatory preservation of neural synchrony over the adult lifespan.

ABSTRACT: We propose that the preservation of functional integration, estimated from measures of neural synchrony, is a key objective of neurocompensatory mechanisms associated with healthy human ageing. To support this proposal, we demonstrate how phase-locking at the peak alpha frequency in Magnetoencephalography recordings remains invariant over the lifespan in a large cohort of human participants, aged 18-88 years. Using empirically derived connection topologies from diffusion tensor imaging data, we create an in-silico model of whole-brain alpha dynamics. We show that enhancing inter-areal coupling can cancel the effect of increased axonal transmission delays associated with age-related degeneration of white matter tracts, albeit at slower network frequencies. By deriving analytical solutions f

SUBMITTER: Pathak A 

PROVIDER: S-EPMC9184644 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature