Imputed expression of schizophrenia-associated genes and cognitive measures in patients with schizophrenia.

ABSTRACT:

Background

Cognitive dysfunction is a core manifestation of schizophrenia and one of the best predictors of long-term disability. Genes increasing risk for schizophrenia may partly act through the modulation of cognition.

Methods

We imputed the expression of 130 genes recently prioritized for association with schizophrenia, using PsychENCODE variant weights and genotypes of patients with schizophrenia in CATIE. Processing speed, reasoning, verbal memory, working memory, vigilance, and a composite cognitive score were used as phenotypes. We performed linear regression models for each cognitive measure and gene expression score, adjusting for age, years of education, antipsychotic treatment, years since the first antipsychotic treatment and population principal components.

SUBMITTER: Fabbri C 

PROVIDER: S-EPMC9184669 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature