Profiling of circulating chromosome 21-encoded microRNAs, miR-155, and let-7c, in down syndrome.

ABSTRACT:

Background

Down syndrome (DS) is the most common chromosomal survival aneuploidy. The increase in DS life expectancy further heightens the risk of dementia, principally early-onset Alzheimer's disease (AD). AD risk in DS is higher, considering that this population may also develop metabolic diseases such as obesity, dyslipidemias, and diabetes mellitus. The extra genetic material that characterizes DS causes an imbalance in the genetic dosage, including over-expression of AD's key pathophysiological molecules and the gene expression regulators, the microRNAs (miRNAs). Two miRNAs, chromosome 21-encoded, miR-155, and let-7c, are associated with cognitive impairment and dementia in adults; but, expression dynamics and relationship with clinical variables during the DS's lifespan had r

SUBMITTER: Perez-Villarreal JM 

PROVIDER: S-EPMC9184673 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature