Amygdalar Functional Connectivity Differences Associated With Reduced Pain Intensity in Pediatric Peripheral Neuropathic Pain.

ABSTRACT:

Background

There is evidence of altered corticolimbic circuitry in adults with chronic pain, but relatively little is known of functional brain mechanisms in adolescents with neuropathic pain (NeuP). Pediatric NeuP is etiologically and phenotypically different from NeuP in adults, highlighting the need for pediatric-focused research. The amygdala is a key limbic region with important roles in the emotional-affective dimension of pain and in pain modulation.

Objective

To investigate amygdalar resting state functional connectivity (rsFC) in adolescents with NeuP.

Methods

This cross-sectional observational cohort study compared resting state functional MRI scans in adolescents aged 11-18 years with clinical features of chronic peripheral NeuP (n = 17), recruited f

SUBMITTER: Verriotis M 

PROVIDER: S-EPMC9184677 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature