Epirubicin Enhances the Anti-Cancer Effects of Radioactive ¹²⁵I Seeds in Hepatocellular Carcinoma via Downregulation of the JAK/STAT1 Pathway.

ABSTRACT: The application and promotion of ¹²⁵I seed implantation technology have increased the safety and effectiveness of the clinical treatment of advanced hepatocellular carcinoma (HCC). Epirubicin (EPI) is a traditional anthracycline chemotherapy agent that has minimal side effects and has been widely used in the clinical treatment of HCC. We hypothesized that EPI would enhance the anti-cancer effects of ¹²⁵I seeds via the JAK/STAT1 signaling pathway. Thus, we aimed to investigate whether EPI could enhance the radiosensitivity of HCC cells to ¹²⁵I and determine the underlying molecular mechanism. This basic study was conducted in an animal laboratory at Shandong University. BALB/C male nude mice were used, and all animals were fed and treated accor

SUBMITTER: Guo L 

PROVIDER: S-EPMC9184686 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature