Immunological role and prognostic potential of CLEC10A in pan-cancer.

ABSTRACT:

Objectives

CLEC10A is expressed in a variety of cells, involved in a variety of biological pathways including immune response, and is closely related to the development of tumor immune response. However, the role of CLEC10A from a pan-cancer perspective has not yet been analyzed, and its role in human cancer prognosis and immunology remains largely unclear.

Methods

We studied the expression levels of CLEC10A and investigated its prognostic value in various cancers across distinct datasets including Oncomine, cBioPortal, and TCGA, and conducted immunohistochemical experiments using fresh bladder cancer and breast cancer samples to verify the results. In addition, we also performed GSEA of CLEC10A and explored the relationship between CLEC10A expression and immune infiltration

SUBMITTER: Qin Y 

PROVIDER: S-EPMC9185031 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature