Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma.

ABSTRACT:

Background

In the contemporary era of cancer immunotherapy, an abundance of clinical and translational studies have reported radiotherapy (RT) and immunotherapies as a viable option for immunomodulation of many cancer subtypes, with many related clinical trials ongoing. In locally advanced disease, chemotherapy or chemoradiotherapy followed by surgical excision of the tumour remain the principal treatment strategy in oesophageal adenocarcinoma (OAC), however, the use of the host immune system to improve anti-tumour immunity is rapidly garnering increased support in the curative setting.

Aim

To immunophenotype OAC patients' immune checkpoint (IC) expression with and without radiation and evaluate the effects of checkpoint blockade on cell viability.

Methods

In the cont

SUBMITTER: Donlon NE 

PROVIDER: S-EPMC9185220 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature