Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging.

ABSTRACT: The arrival of cell-based therapies is a revolution in medicine. However, its safe clinical application in a rational manner depends on reliable, clinically applicable methods for determining the fate and trafficking of therapeutic cells in vivo using medical imaging techniques─known as in vivo cell tracking. Radionuclide imaging using single photon emission computed tomography (SPECT) or positron emission tomography (PET) has several advantages over other imaging modalities for cell tracking because of its high sensitivity (requiring low amounts of probe per cell for imaging) and whole-body quantitative imaging capability using clinically available scanners. For cell tracking with radionuclides, ex vivo direct cell radiolabeling, that is, radiolabeling cells before their administration, i

SUBMITTER: Gawne PJ 

PROVIDER: S-EPMC9185691 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature