A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers.

ABSTRACT: Air pollution is recognized as causal factor for cardiovascular disease (CVD) and is associated with multiple CVD risk factors. Substantial research effort has been invested in understanding the linkages between genetic variation and CVD risk, resulting in over 50 CVD-associated genetic loci. More recently, gene-air pollution interaction studies have quantified the contribution of genetic variation to inter-individual heterogeneity in air pollution health risks, and aided in elucidating mechanisms of air pollution exposure health risks. Here, we perform a comprehensive review of gene-air pollution interaction studies for CVD, as well as risk factors and emerging CVD biomarkers. The literature review revealed that most published interaction studies have been candidate gene studies, causing

SUBMITTER: Ward-Caviness CK 

PROVIDER: S-EPMC9185701 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature