Bioactive lipid screening during respiratory tract infections with bacterial and viral pathogens in mice.

ABSTRACT:

Introduction

Respiratory tract infections are a worldwide health problem for humans and animals. Different cell types produce lipid mediators in response to infections, which consist of eicosanoids like hydroxyeicosatetraenoic acids (HETEs) or oxylipins like hydroxydocosahexaenoic acids (HDHAs). Both substance classes possess immunomodulatory functions. However, little is known about their role in respiratory infections.

Objectives

Here, we aimed to analyze the lipid mediator imprint of different organs of C57BL/6J mice after intranasal mono-infections with Streptococcus pneumoniae (pneumococcus), Staphylococcus aureus or Influenza A virus (IAV) as wells as pneumococcal-IAV co-infection.

Methods

C57BL/6J mice were infected with different pathogens and lungs, spleen, a

SUBMITTER: Schultz D 

PROVIDER: S-EPMC9185708 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature