Ontology highlight
ABSTRACT:
SUBMITTER: Artzy-Schnirman A
PROVIDER: S-EPMC9185737 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Artzy-Schnirman Arbel A Abu-Shah Enas E Chandrawati Rona R Altman Efrat E Yusuf Norkhairin N Wang Shih-Ting ST Ramos Jose J Hansel Catherine S CS Haus-Cohen Maya M Dahan Rony R Arif Sefina S Dustin Michael L ML Peakman Mark M Reiter Yoram Y Stevens Molly M MM
Nano letters 20220526 11
Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect and efficiently target rare autoreactive T-cell populations that are major drivers of these conditions. Here, we develop a unique artificial antigen-presenting cell (aAPC) system from biocompatible polymer particles that allows specific encapsulation of bioactive ingred ...[more]