Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation.

ABSTRACT:

Background & aims

Microbiota composition and mechanisms of host-microbiota interactions in the esophagus are unclear. We aimed to uncover fundamental information about the esophageal microbiome and its potential significance to eosinophilic esophagitis (EoE).

Methods

Microbiota composition, transplantation potential, and antibiotic responsiveness in the esophagus were established via 16S ribosomal RNA sequencing. Functional outcomes of microbiota colonization were assessed by RNA sequencing analysis of mouse esophageal epithelium and compared with the human EoE transcriptome. The impact of dysbiosis was assessed using a preclinical model of EoE.

Results

We found that the murine esophagus is colonized with diverse microbial communities within the first month of life. T

SUBMITTER: Brusilovsky M 

PROVIDER: S-EPMC9185752 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature