Vortioxetine vs. Other Antidepressants in Patients with Major Depressive Episode With or Without Substance Use Disorder.

ABSTRACT:

Background

Major Depressive Episodes (MDEs) may characterise many psychiatric disorders. Its pharmacotherapy is laid with unmet needs, rendering the testing of new drugs necessary.

Objective

To compare the effects of vortioxetine with those of other antidepressants (OADs) in a 1-year naturalistic setting.

Methods

We included 126 adult patients with anMDE in the course of major depressive (MDD), bipolar (BD), or schizophrenia spectrum disorders (SSOPDs), with or without substance use disorder (SUD), who received 5-20 mg/day oral vortioxetine, and compared them with 100 patients receiving OADs at baseline and after 1, 3, 8, and 12 months on their scores on the MADRS, the CGIS, the 24-item BPRS, the YMRS, the Hamilton Anxiety Rating Scale, a Visual Analogue Scale for cra

SUBMITTER: Kotzalidis GD 

PROVIDER: S-EPMC9185761 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature