Loss-of-heterozygosity facilitates a fitness valley crossing in experimentally evolved multicellular yeast.

ABSTRACT: Determining how adaptive possibilities do or do not become evolutionary realities is central to understanding the tempo and mode of evolutionary change. Some of the simplest evolutionary landscapes arise from underdominance at a single locus where the fitness valley consists of only one less-fit genotype. Despite their potential for rapid evolutionary change, few such examples have been investigated. We capitalized on an experimental system in which a significant evolutionary shift, the transition from uni-to-multicellularity, was observed in asexual diploid populations of Saccharomyces cerevisiae experimentally selected for increased settling rates. The multicellular phenotype results from recessive single-locus mutations that undergo loss-of-heterozygosity (LOH) events. By reconst

SUBMITTER: Baselga-Cervera B 

PROVIDER: S-EPMC9185828 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature