IVF for unexplained subfertility; whom should we treat?

ABSTRACT:

Study question

Which couples with unexplained subfertility can expect increased chances of ongoing pregnancy with IVF compared to expectant management?

Summary answer

For couples in which the woman is under 40 years of age, IVF is associated with higher chances of conception than expectant management.

What is known already

The clinical indications for IVF have expanded over time from bilateral tubal blockage to include unexplained subfertility in which there is no identifiable barrier to conception. Yet, there is little evidence from randomized controlled trials that IVF is effective in these couples.

Study design, size, duration

We compared outcomes in British couples with unexplained subfertility undergoing IVF (n = 40 921) from registry data to couples with

SUBMITTER: van Eekelen R 

PROVIDER: S-EPMC9185855 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature