Biomimetic nanobubbles for triple-negative breast cancer targeted ultrasound molecular imaging.

ABSTRACT: Triple-negative breast cancer (TNBC) is a highly heterogeneous breast cancer subtype with poor prognosis. Although anatomical imaging figures prominently for breast lesion screening, TNBC is often misdiagnosed, thus hindering early medical care. Ultrasound (US) molecular imaging using nanobubbles (NBs) capable of targeting tumor cells holds great promise for improved diagnosis and therapy. However, the lack of conventional biomarkers in TNBC impairs the development of current targeted agents. Here, we exploited the homotypic recognition of cancer cells to synthesize the first NBs based on TNBC cancer cell membrane (i.e., NB_CCM) as a targeted diagnostic agent. We developed a microfluidic technology to synthesize NB_CCM based on the self-assembly property of cell membran

SUBMITTER: Jugniot N 

PROVIDER: S-EPMC9185914 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature