Cardiovascular health and four epigenetic clocks.

ABSTRACT:

Background

Cardiovascular health (CVH) was defined by the American Heart Association as an integrative idealness of seven clinical or lifestyle factors. Based on populations of European ancestry, recent studies have shown that ideal CVH is associated with a slower aging rate. The aging rate is measured by levels of epigenetic age acceleration (EAA), usually obtained from the residuals of regressing DNA methylation (DNAm) age on chronological age. However, little has been known about the association of CVH with biological aging in Asian populations.

Methods and results

We here analyzed blood DNAm data and clinical/lifestyle factors of 2474 Taiwan Biobank (TWB) participants, to investigate the association of CVH with EAA. CVH was assessed by seven components: smoking status, p

SUBMITTER: Lo YH 

PROVIDER: S-EPMC9185918 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature