Trimethylamine-N-oxide is present in human follicular fluid and is a negative predictor of embryo quality.

ABSTRACT:

Study question

Are levels of trimethylamine-N-oxide (TMAO) in human follicular fluid (FF) related to IVF outcomes?

Summary answer

Higher levels of TMAO are a negative predictor of oocyte fertilization and embryo quality.

What is known already

TMAO is a metabolic product of dietary choline and l-carnitine produced via subsequent enzymatic modifications by the intestinal microbiota and hepatocytes. TMAO promotes inflammatory and oxidative stress pathways and has been characterized as a causative biomarker for the development of cardiometabolic disease.

Study design, size, duration

For the present cross-sectional study, samples (FF and plasma) from 431 modified natural cycle (MNC)-IVF cycles of 132 patients were collected prospectively between October 2014 and Mar

SUBMITTER: Nagy RA 

PROVIDER: S-EPMC9185935 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature