A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function.

ABSTRACT:

Background

Purified cannabidiol (CBD), a non-psychoactive phytocannabinoid, has gained regulatory approval to treat intractable childhood epilepsies. Despite this, artisanal and commercial CBD-dominant hemp-based products continue to be used by epilepsy patients. Notably, the CBD doses used in these latter products are much lower than that found to be effective in reducing seizures in clinical trials with purified CBD. This might be because these CBD-dominant hemp products contain other bioactive compounds, including phytocannabinoids and terpenes, which may exert unique effects on epilepsy-relevant drug targets. Voltage-gated sodium (Na_V) channels are vital for initiation of neuronal action potential propagation and genetic mutations in these channels result in epilepsy

SUBMITTER: Milligan CJ 

PROVIDER: S-EPMC9185959 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature