An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study.

ABSTRACT:

Background

Epigenetic modifications, including DNA methylation (DNAm), are often related to environmental exposures, and are increasingly recognized as key processes in the pathogenesis of chronic lung disease. American Indian communities have a high burden of lung disease compared to the national average. The objective of this study was to investigate the association of DNAm and lung function in the Strong Heart Study (SHS). We conducted a cross-sectional study of American Indian adults, 45-74 years of age who participated in the SHS. DNAm was measured using the Illumina Infinium Human MethylationEPIC platform at baseline (1989-1991). Lung function was measured via spirometry, including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), at visit 2 (1993-1995).

SUBMITTER: Domingo-Relloso A 

PROVIDER: S-EPMC9185990 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature