Thyroid Cancer Screening Using Tumor-Associated DN T Cells as Immunogenomic Markers.

ABSTRACT:

Background

Thyroid nodules are an extremely common entity, and surgery is considered the ultimate diagnostic strategy in those with unclear malignant potential. Unfortunately, strategies aiming to predict the risk of malignancy have inadequate specificity. Our group recently found that the microenvironment of thyroid cancer is characterized by an enhanced immune invasion and activated immune response mediated by double-negative T lymphocytes (DN T) (CD3⁺CD4^-CD8^-), which are believed to enable or promote tumorigenesis. In the present work, we try to use the DN T cells' proportion in thyroid fine-needle aspiration (FNA) material as a predictor of the risk of malignancy.

Methods

We recruited 127 patients and obtained ultrasound-guided FNA sample

SUBMITTER: Imam S 

PROVIDER: S-EPMC9186057 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature