Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Diabetic nephropathy (DN) is a chronic microvascular complication caused by long-term hyperglycemia in patients with diabetes and an important cause of end-stage renal disease. Although some studies have shown that soluble Klotho(sKlotho) levels of patients with DN are lower than those without DN, in the early stage of patients with DN with normal renal function and albuminuria, the change in sKlotho is still controversial.

Aim

This meta-analysis was conducted to statistically evaluate sKlotho levels in patients with DN.

Methods

We searched the following electronic databases: Web of Science, Embase, PubMed, Google Scholar, and China National Knowledge Infrastructure (CNKI). The following search terms were used for the title or abstract: "diabetic kidney dis

SUBMITTER: Xin C 

PROVIDER: S-EPMC9186104 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature