Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels.

ABSTRACT:

Objective

To disclose the nature of cognitive deficits in a cohort of patients with idiopathic autonomic failure (IAF) by exploring the relation among cognitive functions, cardiovascular autonomic failure (AF) and clinical progression to another α-synucleinopathy (phenoconversion).

Methods

We retrospectively identified all patients with a clinical diagnosis of IAF who underwent a comprehensive neuropsychological evaluation, clinical examination and cardiovascular autonomic tests from the IAF-BO cohort. Brain magnetic resonance imaging (MRI) studies and cerebrospinal fluid (CSF) analysis, including neurofilament light chain (NfL), Alzheimer disease core biomarkers, and α-synuclein seeding activity were further evaluated when available. Correlations among cognitive functions,

SUBMITTER: Cani I 

PROVIDER: S-EPMC9186146 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature