Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia.

ABSTRACT:

Objective

Neonatal encephalopathy (NE) is an important cause of mortality and disability worldwide. Therapeutic hypothermia (HT) is an effective therapy, however not all babies benefit. Novel agents are urgently needed to improve outcomes. Melatonin in preclinical studies has promising neuroprotective properties. This meta-analysis assessed the efficacy of melatonin in term animal models of NE on cerebral infarct size, neurobehavioural tests and cell death.

Methods

A literature search was carried out using Embase, MEDLINE and Web of Science (31 May 2021). We identified 14 studies and performed a meta-analysis with a random effects model using standardised mean difference (SMD) as the effect size. The risk of bias was assessed using the Systematic Review Centre for Laboratory

SUBMITTER: Pang R 

PROVIDER: S-EPMC9186150 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature