Sciatic nerve microvascular permeability in type 2 diabetes decreased in patients with neuropathy.

ABSTRACT:

Objectives

Clinical and histological studies have found evidence that nerve ischemia is a major contributor to diabetic neuropathy (DN) in type 2 diabetes (T2D). The aim of this study was to investigate peripheral nerve microvascular permeability using dynamic contrast enhanced (DCE) magnetic resonance neurography (MRN) to analyze potential correlations with clinical, electrophysiological, and demographic data.

Methods

Sixty-five patients (35/30 with/without DN) and 10 controls matched for age and body mass index (BMI) underwent DCE MRN of the distal sciatic nerve with an axial T1-weighted sequence. Microvascular permeability (K^trans ), plasma volume fraction (v_p ), and extravascular extracellular volume fraction (v_e ) were determined with th

SUBMITTER: Jende JME 

PROVIDER: S-EPMC9186151 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature