Triptolide promotes degradation of the unfolded gain-of-function Tp53^R175H/Y220C mutant protein by initiating heat shock protein 70 transcription in non-small cell lung cancer.

ABSTRACT:

Background

The mutation rate of the tumor protein P53 (TP53) has been reported to be greater than 50% in non-small cell lung cancer (NSCLC), and gain-of-function (GOF) mutations in unfolded P53 (TP53^R175H and TP53^Y220C) have been associated with poor prognosis. However, the best treatment for patients with NSCLC harboring unfolded mutant P53 (mutp53) remains unclear. Triptolide is a natural compound derived from Tripterygium wilfordii that has shown a strong antitumor effect in a variety of cancers. Our study aimed to explore the GOF mutations in unfolded mutp53 (TP53^R175H and TP53^Y220C) and to clarify the molecular mechanisms by which triptolide regulates the degradation of unfolded mutp53 proteins in NSCLC.

Methods

Two unf

SUBMITTER: Zhou J 

PROVIDER: S-EPMC9186163 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature