Sex dimorphism in response to targeted therapy and immunotherapy in non-small cell lung cancer patients: a narrative review.

ABSTRACT:

Background and objective

Multiple agents have been developed for treating non-small cell lung cancer (NSCLC). However, patients' response to these therapies vary drastically, which indicates a need to tailor therapy. Sex is a readily usable clinical characteristic that has been shown to impact patients' response to drugs. The main objective of this narrative review is to summarize the current state of knowledge, compiled from meta-analyses, on sex differences in treatment efficacy for targeted therapy and immunotherapy in NSCLC. We discuss the interplay of patient characteristics, both molecular and demographic, with sex on how they impact therapeutic response.

Methods

PubMed search was performed with the term "sex/gender differences" with currently FDA approved targeting th

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9186178 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature