Ventilation heterogeneity imaged by multibreath wash-ins of hyperpolarized ³ He and ¹²⁹ Xe in healthy rabbits.

ABSTRACT:

Key points

Multibreath imaging to estimate regional gas mixing efficiency is superior to intensity-based single-breath ventilation markers, as it is capable of revealing minute but essential measures of ventilation heterogeneity which may be sensitive to subclinical alterations in the early stages of both obstructive and restrictive respiratory disorders. Large-scale convective stratification of ventilation in central-to-peripheral directions is the dominant feature of observed ventilation heterogeneity when imaging a heavy/less diffusive xenon gas mixture; smaller-scale patchiness, probably originating from asymmetric lung function at bronchial airway branching due to the interaction of convective and diffusive flows, is the dominant feature when imaging a lighter/more diffusive h

SUBMITTER: Hamedani H 

PROVIDER: S-EPMC9186264 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature