Multiple Roles of Ret Signalling During Enteric Neurogenesis.

ABSTRACT: The majority of the enteric nervous system is formed by vagal neural crest cells which enter the foregut and migrate rostrocaudally to colonise the entire length of the gastrointestinal tract. Absence of enteric ganglia from the distal colon are the hallmark of Hirschsprung disease, a congenital disorder characterised by severe intestinal dysmotility. Mutations in the receptor tyrosine kinase RET have been identified in approximately 50% of familial cases of Hirschsprung disease but the cellular processes misregulated in this condition remain unclear. By lineage tracing neural crest cells in mice homozygous for a knock-in allele of Ret (Ret^51/51), we demonstrate that normal activity of this receptor is required in vivo for the migration of enteric nervous sy

SUBMITTER: Natarajan D 

PROVIDER: S-EPMC9186293 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature