Gut Microbiota Dysbiosis in BK Polyomavirus-Infected Renal Transplant Recipients: A Case-Control Study.

ABSTRACT:

Background

BK polyomavirus infection results in renal allograft dysfunction, and it is important to find methods of prediction and treatment. As a regulator of host immunity, changes in the gut microbiota are associated with a variety of infections. However, the correlation between microbiota dysbiosis and posttransplant BK polyomavirus infection was rarely studied. Thus, this study aimed to characterize the gut microbiota in BK polyomavirus-infected renal transplant recipients in order to explore the biomarkers that might be potential therapeutic targets and establish a prediction model for posttransplant BK polyomavirus infection based on the gut microbiota.

Methods

We compared the gut microbial communities of 25 BK polyomavirus-infected renal transplant recipients with 23

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9186314 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature