Test-retest and repositioning effects of white matter microstructure measurements in selected white matter tracts.

ABSTRACT: We used intra-class effect decomposition (ICED) to evaluate the reliability of myelin water fraction (MWF) and geometric mean T₂ relaxation time (geomT_2IEW) estimated from a multi-echo MRI sequence. Our evaluation addressed test-retest reliability, with and without participant re-positioning, for seven commonly assessed white matter tracts: anterior and posterior limbs of the internal capsule, dorsal and ventral branches of the cingulum, the inferior fronto-occipital fasciculus, the superior longitudinal fasciculus, and the fornix in 20 healthy adults. We acquired two back-to-back scans in a single session, and a third after a break and repositioning the participant in the scanner. For both indices and for all white matter tracts assessed, reliability for an immediate

SUBMITTER: Anand C 

PROVIDER: S-EPMC9186506 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature