Examining age-dependent DNA methylation patterns and gene expression in the male and female mouse hippocampus.

ABSTRACT: DNA methylation is a well-characterized epigenetic modification involved in numerous molecular and cellular functions. Methylation patterns have also been associated with aging mechanisms. However, how DNA methylation patterns change within key brain regions involved in memory formation in an age- and sex-specific manner remains unclear. Here, we performed reduced representation bisulfite sequencing (RRBS) from mouse dorsal hippocampus - which is necessary for the formation and consolidation of specific types of memories - in young and aging mice of both sexes. Overall, our findings demonstrate that methylation levels within the dorsal hippocampus are divergent between sexes during aging in genomic features correlating to mRNA functionality, transcription factor binding sites, and gene reg

SUBMITTER: Chinn CA 

PROVIDER: S-EPMC9186538 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature