Comprehensive analysis of expression profiles and prognosis of TRIM genes in human kidney clear cell carcinoma.

ABSTRACT:

Objective

To determine survival rates and the underlying mechanism of genes in the TRIM family in Kidney Clear Cell Carcinoma (KIRC).

Methods

Transcriptional and survival data of TRIM genes in KIRC patients were retrieved from the UCSC Xena, and GEPIA databases. The function of TRIM genes in KIRC was investigated, focusing on potential ubiquitination, miRNAs regulation, and enrichment analysis. Next, TRIM gene survival values were determined, followed by the development of a survival-related signature.

Results

Only TRIM26 was down expressed in the carcinoma tissue and had a survival value in KIRC relative to control tissues, which was supplied by vitro experiment. The patients with lower expression of TRIM26 would have the chance to live a shorter time. SNRPB, which a

SUBMITTER: Shen J 

PROVIDER: S-EPMC9186766 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature